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Alterations in key metabolic pathways such as glycolysis and oxidative phosphorylation profoundly affect the activation, differentiation and function of B and T cells, monocytes, neutrophils and other immune cells, driving inflammation and tissue injury

Particularly, Lip-1 treatment decreased the abundance of adora2a transcript among the hypoxia-associated adenosinergic system (Figure 2A), which was also confirmed by quantitative reverse transcriptase PCR (qRT-PCR) (Figure 2B)

The applicant provided 10 studies to support these claims, as well as one background article about the ( importance of donor site morbidity