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Okun, M

& Mochizuki, H

Recently, multiple findings identified sex differences in microglia, but sex differences in astrocytes remain elusive despite their extensive interactions with microglia

Future research should prioritize longitudinal human studies that move beyond self-reports to include objective measurements of FKBP51 expression levels and cytokine profiles (e.g., IL-6, TNF-, CRP) to quantify homeostasis restoration. Furthermore, investigations into the potential reversibility of epigenetic patterns, such as DNA methylation of NR3C1 and FKBP5, through long-term cannabinoid therapy are necessary