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For example, a nanogel PMNG carrying the chemotherapy drug doxorubicin was prepared by crosslinking carboxymethyl chitosan (CMCS)-derived multiple metformin (PolyMetCMCS) with cystamine, and then coated with hyaluronic acid on its surface to form the nanogel D@HPMNG, which can effectively remodel the TME by reprogramming the phenotype of TAMs and recruiting intratumoral CD8 + T cells thereby significantly inhibiting tumor growth (198)

Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment

The doctors at Rosh Maternal & Fetal Medicine have extensive experience diagnosing ovarian cysts and determining the best treatment