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33 The MyD88-dependent TLR signaling involves activation of IRAK family of kinases, which in turn stimulate the E3 ubiquitin ligase activity of TRAF6, allowing TRAF6 to undergo self-ubiquitination and to conjugate ubiquitin chains onto other signaling molecules that are involved in the activation of a ubiquitin-dependent kinase, TAK1

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Combining these two wavelengths creates a strong synergistic effect, resulting in ablative results with non-ablative downtime