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not only outraged Republicans but offended even may Democrats when he thumbed his nose as the presidential honor system set by George Washington and arrogantly asserted his right to run for a third term as the nations leader

The idea that smoking makes you skinny comes from the fact that nicotine acts as an appetite suppressant and increases metabolism

Widely prescribed to womem Injecting: Started after the invention of hypodermic needle in 1853 Intravenous use takes 15-30 seconds Subcutaneous/intramuscular takes 3-5 minutes Snorting: Self-limiting method The more snorted, the less absorption due to constriction of capillaries in the nose Destructive to nasal passages COCAINE: Routes of Administration Mucosal & contact absorption Can be absorbed through mucosal tissue in nose, mouth, rectum & vagina Delivery method is also used for dental work, minor surgeries Smoking: First introduced in 1914, but high temperature was needed to keep cocaine cigarettes going Mid-1970s, cocaine hydrochloride was chemically altered into freebase Fastest form to reach brain Highly addictive COCAINE: Physical and Mental Effects Metabolism: Quickly metabolized and disappears faster than methamphetamine Medical Use: Only naturally occurring local anesthetic Used to numb nasal passages, eyes, throat, and chronic sores Neurochemistry & Central Nervous System Forces relase of norepinephrine, epinephrine and dopamine Blocks re-absorption so more intense stimulation Blocks 60-70% of dopamine reuptake Too much dopamine can over stimulate brains fright center causing paranoia