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Consider the total cost of formulation integration, including any required stabilizers or specific handling needs

When present in the nucleus, these aggregates sequester transcription factors resulting in gene expression alterations (Labbadia and Morimoto, 2013), while when present in the cytosol, they may bind to diverse proteins resulting in an altered autophagy-lysosome pathway, reduced protein translation, synaptic dysfunction, reduced axonal transport, mitochondrial toxicity, and energy imbalance among others (Labbadia and Morimoto, 2013

Sci Total Environ 662:7787 Naylor C, Rodrigues C (1995) Development of a test method for Chironomus riparius using a formulated sediment

In addition to the abovementioned immunoglobulins and lactotransferrin, we have also identified glycosylated sites in host defense proteins such as haptoglobin and clusterin