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Our group has recently described that NKX2-1 induces dependency on de novo ser/gly synthesis to control ATP supply, nucleotide metabolism and redox homeostasis

Vondriska, T

From six months to one year of use, the percent of patients who experienced at least 75% of repigmentation on their face increased from 30% to nearly 50%

2.2.2 mRNA delivery RNA-based medicine has emerged as an alternative to DNA-based medicine due to technological breakthroughs such as the Nobel Prize winning development of nucleoside base modifications (111), which alongside other design features have endowed synthetic RNA constructs with greater stability and decreased immunogenicity (112)