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Category 2 means FDA identified a significant safety risk, so it should not be compounded

The shape of the curve provides important information about what is occurring in solution during the titration

According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects

Approximately Healthline spoke with Gantt Galloway, PharmD, senior scientist in the Addiction & Pharmacology Research Laboratory at the California Pacific Medical Center Research Institute in San Francisco, California, to learn about which ones work best