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Figure 1 Figure 2 Although recent advances in RA metabolism research have yielded significant insights into these pathogenic mechanisms, there are considerable challenges in translating this knowledge into effective metabolic pathway-targeted therapies

MAK071) and a lactate assay kit (Sigma-Aldrich, Cat

Kaempferol efficacy in metabolic diseases: molecular mechanisms of action in diabetes mellitus, obesity, non-alcoholic fatty liver disease, steatohepatitis, and atherosclerosis

The use of reverse pharmacology on traditional MPs and integrating network pharmacology to understand complex biological interactions is strongly recommended for advancing drug discovery today