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Description

First, and perhaps most importantly, always remember that 5-Amino-1MQ is strictly for research purposes

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Mechanisms of action Anti-CD38 antibodies exert their therapeutic effects via direct effector mechanisms on MM cells (i.e., CD38 enzymatic inhibition, direct induction of apoptosis) and through Fc-dependent immune mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), complement-directed cytotoxicity (CDC), and antibody-directed cellular phagocytosis (ADCP) (Fig

However, the treatment with Daratumumab leads to a rapid elimination (85~90%) of CD38 + NK cells, lasting up to 6 months after the treatment [94, 120]