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A series of systematic reviews was conducted to evaluate the hypothesis that DHEA or DHEAS levels are associated with ASD, autism spectrum traits, or aspects of brain development relevant to autism

An example of such amino acid substitution is the replacement of N297 by a glycine or an alanine

The effect is not usually instantaneous

HYP can successfully reach the brain through the BBB, and the metabolic process is rapid, reaching a peak value about 0.5 h after entering the brain, and the basic metabolism is complete within 3 h (100) (see Table 6 )