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Regulatory properties of brain glutamate decarboxylase

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Abbreviations IBD: Inflammatory bowel disease CD: Crohns disease anti-TNF: Anti-tumor necrosis factor NF-B: Nuclear factor kappa light chain enhancer of activated B cells GWA: Genomics Wide Association NOD2: Nucleotide-binding oligomerization domain-containing protein 2 MAPK/ERK: Mitogen-activated protein kinase IL-3: Interleukin-3 IL-12: Interleukin-12 JAK 3: Janus Kinase 3 MDP: Muramyl dipeptide IRGM: Immunity related GTPase family M IFN-: Interferon-gamma Th17: T helper 17 TLR-2: Toll-like receptor -2 ATG16L1: Autophagy-related 16-like 1 CARD 15: Caspase recruitment domain 15 IL23R: Interleukin 23- receptor LRRK2: Leucine-rich repeat kinase 2 TGF-: Transforming growth factor- RIPK2: Receptor-interacting protein serine-threonine kinase 2 IKB: Inhibitor of kinase B- CCR6: Chemokine receptor 6 Foxp3: Forkhead box P3 STAT3: Signal transducer and activator of transcription 3 TYK2: Tyrosine kinase 2 ATG7/5: Autophagosome 7/5 MHC: Major histocompatibility complex CXCR3: Chemokine receptor 3 References GBD 2017 Inflammatory bowel disease collaborators

Griffiths, C.E.M