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Further research is required to uncover the cancer-modulatory effects of RTL1 in vivo

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In PD there is slow destruction of dopaminergic neurons in the substantia nigra, resulting in reduced dopamine levels in the brain ( Neurotrophic factors like glial cell-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) have emerged as possible agents to promote dopaminergic neuron survival and function in preclinical PD models ( 3.3 Huntington's disease (HD) HD is caused by a mutation in the Huntingtin protein, which results in the aggregation of this protein in the neurons of HD patients ( 4 Targeting blood-brain barrier by nanoparticles The blood-brain barrier (BBB) functions include supplying the brain with nutrients, protecting it, and preserving ionic equilibrium to maintain brain architecture and integrity

HDL have also been reported to induce cell signaling through SR-BI