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Alexandria Long, Director of Cleanup and Compliance, ODASD(EMR)

MSU crystals activate the Mitogen-activated protein kinase (MAPK)/NF-B and Janus kinase-1 (JAK-1) - signal transducers and activators of transcription1/3 (STAT1/3) signaling pathways in macrophages, inducing M1 macrophages polarization and releasing M1 macrophages-associated factors TNF, IL-1, and IL-6 (66, 70)