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Lehraiki A, Abbe P, Cerezo M, et al

53 Mirvetuximab soravtansine showed limited single-agent activity and likely failed to meet their primary endpoint in phase III trial due to insufficient biomarker stratification

After 24 h incubation, the medium was carefully aspirated, and the wells washed twice with PBS, and stained with 100 L resazurin dye (0.4% v/v from stock 1 g/100 ml)

These include: a) Aldh1a1, Aldh2, Aldh1b1, Cat, Cyp2e1, Adh3a1 and Gclm single knockouts (KO) b) Aldh1a1 and Aldh3a1 knock-in lines (both have mutated the Cys-302 of the active site) c) Aldh1a1/Aldh1b1, Aldh1b1/Aldh2, Cat/Cyp2e1 and Gclm/Nrf2 double knockouts (DKO) d) Conditional Gclc floxed strain e) Hepatocyte-specific Gclc knockout Funded by NIAAA (R24AA022057) Contact Please send inquiries and requests to: Dr