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More recently, gene rearrangements have been reported that give rise to AR versions that lack a functional ligand-binding domain (so-called AR variants (ARvs), making them unresponsive to ADT and constitutively active even in the absence of androgens [36]

10.1038/nrn3453 380 RushT.LiuX.NowakowskiA

A paradigm shift from resistance to resilience-focused strategies is emerging, emphasising the need for cities to 'bounce forward' to new equilibria rather than returning to pre-flood normality (Hegger et al., 2016)