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The data indicate that bacterial metabolites entering the circulation can substantially alter the host metabolisms via interactions with appropriate host membrane or nuclear receptors ( Intestinal TJ proteins are involved in the regulation of barrier status which defines how the composition of the microbiota in the gut interacts with the immune cells

In conclusion, in order to understand the exact relationship of retinol and -carotene in thyroid disorders, further in vivo and in vitro studies are required ( Figure 2 shows the proposed molecular mechanism of action

This may be linked to improved cellular function and reduced metabolic stress

( MGMT) methylation