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In animals that had been kept for 7 days after dosing, no histological abnormalities were found other than engorgement of the liver and kidneys (Marrs et al., 1982)

The proposed mechanisms include upregulation of beta-3 adrenergic receptors in adipose tissue, activation of the cAMP-PKA lipolytic cascade through enhanced catecholamine sensitivity, direct or indirect inhibition of acetyl-CoA carboxylase (ACC) reducing de novo lipogenesis by approximately 43-57% in vitro, and activation of hormone-sensitive lipase (HSL) with increased glycerol release

Additionally, lifestyle changes such as increasing physical activity, reducing stress, getting regular sleep, and eating a healthy diet can help patients manage their symptoms