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Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) ( ME/CFS impacts all ages, races, and socioeconomic groups ( Due to the disabling symptoms which include cognitive and physical impairment worsened by exertion ( In this review paper, we will focus on describing ME/CFS in terms of symptoms, severity and burden, diagnostic criteria, causes and triggers

These occur because vitamin B12 is essential for maintaining the protective sheath around nerves

Glutathione encourages its breakdown by acting as a substrate of the enzyme formaldehyde dehydrogenase

During sepsis, alveolar macrophages are activated and they are able to secrete inflammatory cytokines to affect inflammatory environment