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Expanding the Indications of Existing Chemotherapies for the Treatment of Brain Cancer Advances in our understanding of tumorigenic pathways have allowed existing anticancer agents to be successfully repurposed to treat other cancers that share common signaling pathways (17)

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The anatomical specialization of astrocytic endfeet enables these cells to rapidly and efficiently remove neurotransmitters from the synaptic cleft to maintain homeostasis, and to provide glutamine to replenish neurotransmitter pools in both glutamatergic and GABAergic neurons