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Supplementation strategies vary depending on the underlying cause of deficiency or risk factors: Oral supplements (typically 25-2000 micrograms daily) are suitable for individuals with adequate intrinsic factor production but insufficient dietary intake Sublingual or buccal preparations have no proven superiority over standard oral tablets at equivalent doses Intramuscular injections (usually 1000 micrograms of hydroxocobalamin) are the preferred treatment for pernicious anaemia and severe malabsorption

It is not an FDA-approved medication for over-the-counter use, and regulatory status varies by country

Another study also evaluated the efficacy of low-dose riboflavin in migraine headaches, compared with propranolol