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Additionally, IGF-1 levels were reported to rise by about 28%, hinting at an improved functionality of the growth hormone-IGF-1 axis

CA: A Cancer Journal for Clinicians

(Mechanism of Action) Ipamorelin enhances growth hormone production through: Ghrelin Receptor Activation : Mimics ghrelin by binding to the growth hormone secretagogue receptor (GHS-R), stimulating the pituitary gland to release GH

The documented synergy between GHRH and GHRP pathways across multiple preclinical models, combined with the matched temporal profiles and preserved selectivity of this specific combination, provides strong mechanistic rationale for their paired use