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It is acid-stable, soluble at lower pH, penetrates in high concentrations into gastric tissue and mucus and acts both at the extracellular and intracellular levels exerting excellent antimicrobial activity

Patients should be monitored closely for bleeding while receiving systemic ketorolac, receiving concurrent myelosuppressive chemotherapy, corticosteroid therapy, or anticoagulant therapy, tobacco smoking patients, or in patients with alcoholism

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Importantly, this study also demonstrates limited impacts of metformin treatment on the metabolic profile of non-cancer rectal tissue, supporting its potential utility as a radiosensitising agent in the management of rectal cancer