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This study pioneered an in vivo self-assembly strategy to develop a PKM2 allosteric converter, dually suppressing the Warburg effect and chemoresistance in renal cell carcinoma (RCC) through an enzyme-responsive self-assembly and sustained activation mechanism

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In the following, we will introduce the utilization of peptides to modulate the functions of these cells, thereby improving the immunosuppression within the TME of PCa Figure 1

However, clinical translation still faces challenges, such as administration routes, dosage optimization, and toxicity assessment, which require further investigation