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Aldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas

This unique capability makes GPX4 the primary defense against ferroptotic cell death, managing oxidative stress and maintaining membrane integrity by converting potentially lethal lipid hydroperoxides into nontoxic lipid alcohols (Figure 1) [19]

for example, when hepatocytes secrete GSH, another cell can hydrolyze it in its precursors (cysteinyl-glycine and glutamate) by -glutamyl-transpeptidase (-GT, EC 2.3.2.2) that are expressed on the outer plasma membrane

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