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AMPK-mTORC1 signaling is responsible for autophagy activation in vitiligo melanocytes We recently demonstrated that melanocytes obtained from normally pigmented vitiligo skin exhibit defects in mitochondrial metabolism 2

Scutellaria baicalensis Georgi induces caspase-dependent apoptosis via mitogen activated protein kinase activation and the generation of reactive oxygen species signalling pathways in MCF-7 breast cancer cells

This conservative approach allows for gradual cellular adaptation while minimizing the potential for excessive detoxification responses