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Unfortunately, at present, no more effective measures can completely alleviate or reverse tissue fibrosis, so symptomatic treatments for fibrosis-related symptoms are commonly adopted, like non-steroidal anti-inflammatory drugs (NSAIDs) for muscular pain, injection of botulinum toxin for dystonia, and oxygen therapy or mechanical ventilation for respiratory failure

These mitokines interact with several neurotrophic and growth factors, notably brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) [14]

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Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S (2000) Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains