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In addition, heat stress may affect the spatial distribution of mitochondria within the oocyte, possibly through alterations in the cytoskeleton 15 , as well as the proportion of highly polarized mitochondria and the expression of developmentally important genes 16,17

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For example, abrogation of the microbiome by antibiotic treatment reduced the tumour burden, suggesting a functional role of the microbiome in SCC therapy response [77]