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Although alpha-adrenergic blockers and 5-alpha reductase inhibitors have been recognized for their efficacy in treating mild BPH, long-term use may be associated with side effects such as erectile dysfunction, retrograde ejaculation, orthostatic hypotension, and gastrointestinal discomfort

173,174,175 As previously mentioned, IDO and TDO are tryptophan catabolism enzymes, and inhibitors of these enzymes have been developed and evaluated in various clinical trials

Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism