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In Iranian patients, mean serum Cu and zinc levels were also significantly lower in patients with lower segmental and non-segmental vitiligo than in the control group [104]

For example, curcumin, an extract from the rhizome of the plant Curcuma longa mentioned above, inhibits ROS production and degrades KEAP1 to activate the NRF2/ARE pathway [455]

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The published paper includes a review of the literature, in which DAdamo and colleagues detail the many alternative approaches that have succeeded, but have been ignored by orthodox medicine, even when published, possibly due to lack of blinding, which is challenging for such interventions