glutathione shunt Hexose Monophosphate - an overview Kap 14d - Hexose Monophosphate

Glutathione is a key component of the antioxidant system, which protects the body from free radicals at the cellular level

Antioxidants 10(2):277

Glutathiones main roles include: Neutralizing harmful free radicals Acting as a cofactor for several antioxidant enzymes Regenerating vitamins C and E Neutralizing free radicals produced by Phase I liver metabolism of chemical toxins, including formaldehyde, acetaminophen, benzpyrene, and many other compounds Participating in Phase I and Phase II detoxification reactions Adhering to toxins and heavy metals (including mercury) before carrying them out of the body Regulating cellular proliferation and apoptosis Participating in mitochondrial function and the maintenance of mitochondrial DNA Essentially, glutathione is crucial for shielding cells from endogenous and exogenous reactive oxygen and nitrogen species, as well as dealing directly with the causes of oxidative stress such as mercury and pollutants

In the early 1960s, researchers found that workers with chronic exposure to organophosphates, mainly in insecticides and after sheep dipping, experienced persistent central nervous system (CNS) changes (153)