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In addition, some indirect evidence also points to the benefit of downregulating B cell NF-B to control excess inflammation

One example I like to use that I think really illustrates where testing would wind up being really important is, lets say, imagine you have a woman who has the genetics for hemochromatosis and doesnt know it and because of the amount of menstrual fluid that she loses is lifelong predisposed to anemia

To evaluate this concern, we examined the functional activity of these alkaloids using a 5-HT 2B Rphosphoinositide hydrolysis assay with 5-HT and SB 206553 as the positive and inverse agonist controls (respectively, Figure 6B)

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