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Proposed reasons for CD38 reduction with daratumumab include endocytosis, trogocytosis by granulocytes and monocytes, and packaging of daratumumab:CD38 complexes into MVs [82]

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[1] It tested once-weekly cagrilintide across a dose range and compared it with both placebo and an active comparator (liraglutide 3.0 mg)

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