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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

(this doesnt need to be specifically within a population with dementiathis is for all people with confirmed vitamin B12 deficiency) Database : EBM Reviews - Cochrane Database of Systematic Reviews 2005 to April 2013, EBM Reviews - ACP Journal Club 1991 to May 2013, EBM Reviews - Database of Abstracts of Reviews of Effects 2nd Quarter 2013, EBM Reviews - Cochrane Central Register of Controlled Trials April 2013, EBM Reviews - Cochrane Methodology Register 3rd Quarter 2012, EBM Reviews - Health Technology Assessment 2nd Quarter 2013, EBM Reviews - NHS Economic Evaluation Database 2nd Quarter 2013, Embase 1980 to 2013 Week 22, Ovid MEDLINE(R) 1946 to May Week 4 2013, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations June 03, 2013 Search Strategy: Database: CINAHL Suggested Citation This report should be cited as follows: Masucci L, Goeree R

The honest position is this: there is no head-to-head human bioavailability trial telling you which route is superior for this specific molecule, so the best route is not a settled question

[29] Why do some patients still feel fatigued after injections