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Description

NRC (National Research Council) 2001

Enhanced cartilage regeneration A 2013 study found that when white rabbits suffering from osteoarthritis (OA) were injected with Fragment 176-191 in conjunction with hydrochloric acid (HA), they experienced enhanced cartilage growth compared with those receiving HA injections alone [10]

Therefore, a possible mechanism proposed by the authors is that the activation of the farnesoid X receptor (FXR) by exendin-4 stimulates the expression of FGF15 in the small intestine and inhibits the expression of cytochrome P450 family 7 subfamily A member 1 (Cyp7a1) in the liver through fibroblast growth factor receptor 4 (FGFR4), thereby reducing fecal bile acid excretion and liver bile acid synthesis [75]