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also found that the combination of metformin and Diane-35 improved the oestrous cycle disorders, increased the proliferation and differentiation of ovarian FGCs, and inhibited cell apoptosis in PCOS rats

That said, a significant die-off reaction can also be a signal that detoxification pathways need more supportmore on this below

Additionally, two long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can be synthesized from ALA, but their synthesis may be insufficient under certain conditions, such as during pregnancy and lactation (87, 88)

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