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The translational success stories in fragile X and Rett syndromes indicates that the effectiveness of targeted treatments in animal models can turn into clinical efficacy in humans, provided that studies are well designed, the models are reliable and robust, and that preclinical outcome measures are relevant to patients (Anagnostou, 2012

For example, epidural steroids may take up to two to five days to start providing pain relief, but may continue to provide relief for several months and beyondwhile for some patients, epidural steroids may not prove effective at all

1 Introduction The ketogenic diet (KD) is a high-fat diet that also restricts carbohydrates, and triggers the bodys production of ketones for energy use

Chip 13 , 32533260 (2013)