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GSK-3 inhibition however does not recapitulate all of the protective features of lithium (see Figure 1), and this raises the possibility that their combined use with drugs targeting non-GSK-3-dependent mechanisms of lithium action may exert more effective neuro-protection under accumulating damage in dementia

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Additionally, surgical interventions often involve hardware, such as pins or plates, and carry risks including infection, stiffness, or recurrent instability

Neurology 57:14221427 Arlt S, Muller-Thomsen T, Beisiegel U, Kontush A (2012) Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease