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Emotional states such as anxiety and fear, along with maladaptive cognitions like catastrophizing, modulate central pain pathways and contribute to both pain chronification and poorer treatment outcomes (77, 78)

28 By activating p53, the liver initiates processes that promote cell cycle arrest, DNA repair, and apoptosis in damaged cells, 29 helping to limit the extent of liver injury and facilitating the removal of cells that have sustained significant damage

Our current study attempts to elucidate the role of some other major components of the cytoplasmic Fe-S cluster biogenesis machinery

The associated idea of genomic medicine failed to address the whole individual and outside factors that affect health, propelling the idea of epigenetics as a significant causal factor in disease development, severity and progression