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Another significant group includes carotenoids such as beta-carotene, lutein, and zeaxanthin, which are found in colorful fruits and vegetables like carrots and spinach [203]

Furthermore, oxidative stress impairs nitric oxide (NO) bioavailability, reducing vasodilation and increasing vascular stiffness [188]

Phosphorylation, ubiquitination, and acetylation are common forms of PTMs that interact and collectively regulate protein function and metabolism within the cell

For instance, NRF2 inhibitors, such as Brusatol and Brucein D, promote ubiquitination and proteasomal degradation of NRF2, enhancing chemosensitivity in cancers like AML, endometrial cancer, and pancreatic ductal adenocarcinoma