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12 Elevated glutamate, glutamine and glycine levels in pain-related brain regions, such as the posterior insula and cerebrospinal fluid, which correlate to the levels in pain in fibromyalgia, have been reported in brain spectroscopy studies

doi: 10.3389/fnmol.2022.972308

The amount of total glutathione and GSSG in each sample was normalized by the protein concentration of the sample that was determined by BCA Protein Assay (Thermo Fisher Scientific, Waltham, MA, USA)

Therefore, Mn-SOD dysfunction may result in overproduction of highly reactive oxidants, such as ONOO and OH, which may result in mitochondrial dysfunction and disease development