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Interestingly, Masri et al

However, once their function is impaired, which is manifested as reduced glutamate uptake, dysfunctional K+ buffering, or dysregulated lactate metabolism, increased neuronal excitotoxicity, metabolic disturbance, and aggravated injury occur, thereby promoting the progression of neurodegenerative diseases such as MS, AD, PD, and Huntingtons disease [403, 404]