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The growth of gr mutant was completely inhibited under 20 mM copper ions, while the gr overexpression strain showed a growth advantage over the wild type (Figure 7)

2.2 Mechanism of ferroptosis The sources of lipid ROS that induce ferroptosis are multifaceted, and lipid peroxidation pathways and iron metabolism are increasingly considered to be involved in the ferroptosis process (14) (Figure 1)