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A rare cause is transcobalamin II deficiency, a genetic condition where your body can't transport B12 (also known as cobalamin) in your body

Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice

It affects an enzyme called NNMT, which acts like a metabolic leakdraining away essential components: NAD (crucial for energy production) SAM (the universal methyl donor) This is significant, especially since NNMT is upregulated in conditions such as obesity, diabetes, Alzheimers, Parkinsons, and aging

If that's not enough, magnesium glycinate is a supplement worth discussing with your clinician