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Most recently, don't trust the 2020 assertion on page 15 of "Smoking Cessation: A Report of the Surgeon General" stating: "Proponents of encouraging smokers to quit without treatment, often called quitting "cold turkey," point to data indicating that most smokers who quit successfully do so without medications or any type of formal assistance, as well as to population surveys suggesting that cold-turkey quitters do as well or better than those who use over-the-counter NRTs (Alpert et al

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Several adaptor proteins have emerged as potent regulators of HECT E3 ubiquitin ligases, as they can influence E3 localization and catalytic activity and regulate E3-substrate interactions 12