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21 Antioxidants and Oxidative Stress To protect human cells and organ systems against free radicals, a complex antioxidant system exists

DKN-01, a DKK1-neutralizing monoclonal antibody is being evaluated in a phase I trial in combination with gemcitabine and cisplatin in patients with CCA or gallbladder cancer (NCT02375880), but did not show additional activity beyond gemicitabine/cisplatin alone, which may be due to heterogeneity of differential activity for DKN-01 to different DKK1 expression or the need for increased dose/intensity

I Rahman

Chromatographic separation typically highly increases the protein purification yields, but with higher operational costs