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This pathway begins with the accurate determination of the methylation status of key gene promoters (such as NIS and TSHR) in tumor tissues or circulating tumor DNA (ctDNA) using high-sensitivity techniques such as pyrosequencing or methylation-specific PCR [140, 141]

In the afternoon, we reach Ollantaytambo , an Inca town still inhabited today, where we explore its impressive archaeological site

d , A cross-cohort meta-analysis of associations (logistic regression) between extreme ageotypes versus diagnosis of 9 major age-related diseases annotated in at least 2 independent cohorts