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Other classes of medications that have been effective in controlled clinical trials include trycyclic antidepressants and related agents (e.g., amitriptyline, cyclobenzaprine) [22, 23], mixed serotonin/norepinephrine reuptake inhibitors (e.g., duloxetine) [24], dopamine agonists (e.g., pramipexole) [25], and the sedating hypnotic sodium oxybate [26]