Moreover, probiotics could reduce the intestinal permeability and leaky gut (131), hence reduce the secretion of harmful factors such as LPS, TNF- and RANKL, ultimately ameliorate bone loss and OP development (129, 132, 133) ( Figure 4 )
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It is reported that, higher daily intakes of rice bran for longer duration is needed to induce favorable changes in serum lipid parameters [34]
J Immunol (2009) 182:715562
