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Nature 486 , 346352 (2012)

doi: 10.1152/ajpcell.00105.2009 45 RichelsenBPedersenSBKristensenKBrglumJDNrrelundHChristiansenJSet al

For example, doxorubicin (DOX) has cardiac side effects that lead to irreversible dilated cardiomyopathy and congestive heart failure, and acetylcarnitine has been shown to prevent cardiac functional and structural damage caused by DOX-induced oxidative stress [289]